Enantioselective bioreduction of ethyl 4, 4, 4-trihalide-3-oxobutanoate by Kluyveromyces marxianus

…, NC Barbosa, ML Bello, FJM Novaes, MCKV Ramos…

Index: Oliveira, Simone Santos De Sousa; Dias, Luiza Rosaria Sousa; Barbosa, Natane Cezario; Bello, Murilo L.; Novaes, Fabio Junior Moreira; Ramos, Maria Da Conceicao Klaus V.; Aquino Neto, Francisco Radler De; Fiaux, Sorele Batista Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3067 - 3070

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Abstract

Resting cells of Kluyveromyces marxianus were used in the bioreduction of ethyl 4, 4, 4- trifluoro-3-oxobutanoate and ethyl 4, 4, 4-trichloro-3-oxobutanoate with 81% and 4% yields and 29% and 73% enantiomeric excess, respectively. The differences observed were attributed to the tri-halide structures.