Total synthesis of the Fusarium toxin equisetin: Proof of the stereochemical relationship of the tetramate and terpenoid sectors

E Turos, JE Audia, SJ Danishefsky

Index: Turos; Audia; Danishefsky Journal of the American Chemical Society, 1989 ,  vol. 111,  # 21  p. 8231 - 8236

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Citation Number: 62

Abstract

Abstract: A total synthesis of the Fusarium mycotoxin equisetin, in a manner that establishes its stereochemistry, is described. The key steps involve a lactonic variation of the ester enolate Claisen rearrangement and a novel construction of a 1-acyltetramic acid from an LN- methylserine derivative and a,% keto ester.