Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

…, A Van Aerschot, G Janssen, E De Clercq

Index: Herdewijn; Balzarini; Baba; Pauwels; Van Aerschot; Janssen; De Clerq Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 10  p. 2040 - 2048

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Citation Number: 141

Abstract

However, this unsaturated guanosine derivative was not isolated nor characterized and its yield was very low. A structure-activity analysis is provided for several base-modified pyrimidine 3'-azido-2 ', 3 '-dideoxynucleosides (la, Id, le, If, lg) and compared with the previously described compounds lh and li. l0 Although some of these compounds (la, le, lh) were previously described by Lin et a1.: these authors only evaluated them against the ...