Tetrahedron letters

A new synthesis of thioflavones

AW Taylor, DK Dean

Index: Taylor, A. W.; Dean, D. K. Tetrahedron Letters, 1988 ,  vol. 29,  # 15  p. 1845 - 1848

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Citation Number: 21

Abstract

Recently, we have been interested in assessing the antifungal activity of a series of substituted derivatives of thioflavone (1) l. In general, thioflavones are readily synthesised by two methods; either the direct condensation of a P-keto ester (eg 3) with a thiophenol in polyphosphoric acld, 2 or the cyclisation of a D-substituted cinnamate (eg 5), itself derived from the constituent thiophenol and an appropriate propiolate (eg 4). 3 We have prepared ...