Design, synthesis and bioevaluation of dihydropyrazolo [3, 4-b] pyridine and benzo [4, 5] imidazo [1, 2-a] pyrimidine compounds as dual KSP and Aurora-A kinase …
R Fu, Q You, L Yang, W Wu, C Jiang, X Xu
Index: Fu, Rong-Geng; You, Qi-Dong; Yang, Lei; Wu, Wu-Tong; Jiang, Cheng; Xu, Xiao-Li Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8035 - 8043
Full Text: HTML
Citation Number: 25
Abstract
Four series of dihydropyrazolo [3, 4-b] pyridines and benzo [4, 5] imidazo [1, 2-a] pyrimidines were designed and synthesized as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents by introducing some fragments of Aurora-A kinase inhibitors into our KSP inhibitor CPUYL064. A total of 19 target compounds were evaluated by two related enzyme inhibition assays and a cytotoxicity assay in vitro. The results showed that some target compounds ...
Related Articles:
[Yadlapalli, Rama Krishna; Chourasia; Vemuri, Kiranmayi; Sritharan, Manjula; Perali, Ramu Sridhar Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2708 - 2711]
Acetoacetylation with 2, 2, 6-trimethyl-4H-1, 3-dioxin-4-one: a convenient alternative to diketene
[Clemens, Robert J.; Hyatt, John A. Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2431 - 2435]
Transacetoacetylation with tert-butyl acetoacetate: synthetic applications
[Witzeman, J. Stewart; Nottingham, W. Dell Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1713 - 1718]