Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach

…, KH Nguyen, P de Aguiar Amaral…

Index: Trinh, Thi Thanh Huyen; Nguyen, Khanh Hung; De Aguiar Amaral, Patricia; Gouault, Nicolas Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2042 - 2047

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Citation Number: 17

Abstract

Abstract A new approach to the total synthesis of (−)-epimyrtine has been developed from D- alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.