Tetrahedron

Peptide and pseudopeptide analogues of cholecystokinin, chemical modifications of the met 28-gly 29 region

C Mendre, M Rodriguez, J Laur, A Aumelas, J Martinez

Index: Mendre; Rodriguez; Laur; Aumelas; Martinez Tetrahedron, 1988 ,  vol. 44,  # 14  p. 4415 - 4430

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Citation Number: 17

Abstract

The syntheses of a series of analogues of the C-tenninal hepta-and octa-peptide of cholecystokinin are described in detail. These peptide and pseudopeptide analogues were obtained by modifying the NIe28-Gly29 region, either by replacing the Gly29 residue by D- Alanine, Sarcosine, or by replacing the peptide bond between Nle28 and Gly29 by a “ketomethylene bond”(COCH2), by a'“carba bond”(CH2CH2) or by a “retro-inverso ...