Trifluoro??3??hydroxy??1H??indazolecarboxylic Acids and Esters from Perfluorinated Benzenedicarboxylic Acids

…, C López, RM Claramunt, J Elguero

Index: Medina, Carlos Perez; Lopez, Concepcion; Claramunt, Rosa M.; Elguero, Jose European Journal of Organic Chemistry, 2010 , # 5 p. 890 - 899

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Citation Number: 6

Abstract

Abstract Twelve new 3-hydroxyindazoles, each bearing three fluorine substituents and a CO 2 R group (R= H, CH 3, C 2 H 5) distributed around its 4-, 5-, 6-, and 7-positions, have been synthesized. They were studied by NMR in solution (1 H, 13 C, 15 N, 19 F) and in the solid state (13 C, 15 N). In solution, all of them are 3-hydroxy tautomers: the a form. In the solid state, although the 3-hydroxy tautomers are still the most frequent, there are some cases ...