6-[(Aminoalkyl) amino]-substituted 7H-benzo [e] perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation

…, S Martelli, J Tarasiuk, M Bontemps-Gracz…

Index: Stefanska, Barbara; Dzieduszycka, Maria; Martelli, Sante; Tarasiuk, Jolanta; Bontemps-Gracz, Maria; Borowski, Edward Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 38 - 41

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Citation Number: 23

Abstract

A class of chromophore-modified anthracenediones with an additional pyrimidine ring incorporated into the chromophore system has been obtained in an attempt to provide compounds with diminished peroxidation activity and thus potentially lowered cardiotoxicity. Their synthesis was carried out by the reaction of 6-amino-or 6-hydroxy-7H-benzo [e] perimidin-7-one with a number of alkylamines. Potent activity was demonstrated in vitro ...