Steroids

Synthesis of bile acid 24-acyl glucuronides

J Goto, N Murao, J Oohashi, S Ikegawa

Index: Goto, Junichi; Murao, Naoaki; Oohashi, Junji; Ikegawa, Shigeo Steroids, 1998 ,  vol. 63,  # 4  p. 180 - 185

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Citation Number: 32

Abstract

The synthesis of acyl glucuronides of common bile acids is described. By means of the Mitsunobu reaction employing diethylazodicarboxylate and triphenylphosphine, bile acids were condensed through the inherent C-24 carboxy group with benzyl 2, 3, 4-tri-O-benzyl-d- glucopyranuronate, which was prepared from 1-O-methyl-α-d-glucose. The separation and purification of the β-anomers at the anomeric position of the sugar moiety were attained by ...