Synthesis and evaluation of hepatoprotective activity of some new Mannich bases bearing benztriazole moiety

A Rajasekaran, M Periyasamy

Index: Rajasekaran, Aiyalu; Periyasamy, Muthusamy Journal of the Chilean Chemical Society, 2010 , vol. 55, # 3 p. 366 - 370

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Abstract

A series of benztriazoles bearing Mannich bases (2-10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) ...