Kinetic resolution of fluoroalkyl (E)-vinyl carbinol derivatives by asymmetric epoxidation with titanium-tartrate catalysts.
…, K Kawagoe, M Ito, Y Kobayashi
Index: Hanzawa; Kawagoe; Ito; Kobayashi Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 4 p. 1633 - 1636
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Citation Number: 14
Abstract
Racemic fluoroalkyl (E)-vinyl carbinols (1a-d) were kinetically resolved by Sharpless epoxidation. The optical purity of the resolved alcohols was excellent (98% ee) in mono-and difluoromethyl derivatives (1b and 1c) and moderate (60% ee) in a trifluoromethyl compound
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