Journal of medicinal chemistry

Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1, 4-dihydro-2, 6-dimethyl-3- …

R Shan, SE Howlett, EE Knaus

Index: Shan, Rudong; Knaus, Edward E. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2613 - 2614

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Citation Number: 31

Abstract

The novel (-)-(S)-2 and (+)-(R)-3 enantiomers of 2-nitrooxyethyl 1, 4-dihydro-2, 6-dimethyl-3- nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate were synthesized for evaluation as calcium channel modulators. Determination of their in vitro calcium-channel-modulating