Organocatalytic Multicomponent α??Methylenation/Diels–Alder Reactions: A Versatile Route to Substituted Cyclohexenecarbaldehyde Derivatives

Y Zou, Q Wang, A Goeke

Index: Zou, Yue; Wang, Quanrui; Goeke, Andreas Chemistry - A European Journal, 2008 , vol. 14, # 17 p. 5335 - 5345

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Citation Number: 15

Abstract

Abstract This article describes the design and optimization of an effective organocatalytic three-component domino α-methylenation/Diels–Alder reaction to produce vinyl-substituted cyclohexenecarboxaldehydes in a highly regioselective fashion. In these one-pot transformations, 2-formyl-1, 3-butadienes (4) were prepared in situ from α, β-unsaturated aldehydes and formalin and were subsequently trapped with a variety of buta-1, 3-dienes. ...