Synthesis and neuroleptic activity of some trans-(2-aminomethyl)-cyclopentyl aryl ketones

O Caamaño, F Fernandez, A Eirin, E Uriarte…

Index: Caamano; Fernandez; Eirin; Uriarte; Calleja; Gato; Orallo European Journal of Medicinal Chemistry, 1987 ,  vol. 22,  # 4  p. 311 - 317

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Citation Number: 2

Abstract

Abstract This article describes the synthesis of a series of butyrophenone analogues in which the propyl chain is partially included in a cyclopentane ring. These trans-(2- aminomethyl) cyclopentyl aryl ketones are obtained by reacting (2-bromomethyl) cyclopentyl phenyl ketone or (2-bromomethyl) cyclopentyl p-fluorophenyl ketone with the corresponding heterocyclic amine. The potential neuroleptic activity of these compounds is reported.