A practical and cost-effective synthesis of 6, 7-dimethoxy-2-tetralone

AM Qandil, DW Miller, DE Nichols

Index: Qandil, Amjad M.; Miller, David W.; Nichols, David E. Synthesis, 1999 , # 12 p. 2033 - 2035

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Citation Number: 7

Abstract

Abstract: The cyclic ketone, 6, 7-dimethoxy-2-tetralone, a versatile starting material for many dopaminergic compounds, can be prepared practically, cost-effectively and in good overall yield. The synthesis starts from readily available 3, 4-dimethoxyphenylacetic acid. Ring iodination gave the 2-iodo-4, 5-dimethoxy acid, which was converted to its methyl ester. Palladium (II)-catalyzed Heck cross coupling afforded the expected unsaturated diester, ...