Synthesis and biological evaluation of 3-substituted-benzofuran-2-carboxylic esters as a novel class of ischemic cell death inhibitors

J Suh, KY Yi, YS Lee, E Kim, EK Yum, S Yoo

Index: Suh, Jeehee; Yi, Kyu Yang; Lee, Yun-Suk; Kim, Eunhee; Yum, Eul Kgun; Yoo, Sung-Eun Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6362 - 6365

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Citation Number: 11

Abstract

A series of 3-substituted-benzofuran-2-carboxylic esters was synthesized and evaluated for biological activity as ischemic cell death inhibitors in H9c2 cells and rat primary cardiac myocytes under conditions of oxygen and glucose deprivation. The introduction of a sulfur atom at the three-position substituent of the benzofuran ring markedly improved ischemic cell death inhibitory potency. In particular, 3-[2-(4-nitro-phenylsulfanyl)-acetylamino]- ...