Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands—modeling and binding data don't agree!
…, RT Mosley, ET Birzin, W Chan, ML Hammond
Index: Blizzard, Timothy A.; Mosley, Ralph T.; Birzin, Elizabeth T.; Chan, Wanda; Hammond, Milton L. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1317 - 1321
Full Text: HTML
Citation Number: 4
Abstract
A series of 2-phenylspiroindenediones was prepared. The spiroindenediones were found to be less active than the corresponding spiroindenes as estrogen receptor ligands and failed to demonstrate the receptor subtype selectivity that had been anticipated from molecular modeling.
Related Articles:
The oxidation of a series of phthalyl alcohols
[Bhattacharjee, Debkumar; Popp, Frank D. Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 315 - 320]
[Fujita, Ken-Ichi; Ito, Wataru; Yamaguchi, Ryohei ChemCatChem, 2014 , vol. 6, # 1 p. 109 - 112]
7-Methoxy-3-nitro-2-naphthalenemethanol—a new phototrigger for caging applications
[Singh, Anil K.; Khade, Prashant K. Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4899 - 4902]
A new synthesis of phthalides through β-scission of benzocyclobutenol hypoiodites
[Kobayashi, Kazuhiro; Itoh, Masahito; Suginome, Hiroshi Tetrahedron Letters, 1987 , vol. 28, # 29 p. 3369 - 3372]