Tetrahedron letters

An efficient synthesis of platelet-activating factor (PAF) via 1-0-alkyl-2-O-(3-isoxazolyl)-SN-glycero-3-phosphocholine, a new PAF agonist utilization of the 3- …

N Nakamura, H Miyazaki, N Ohkawa, T Oshima…

Index: Nakamura, Norio; Miyazaki, Hideki; Ohkawa, Nobuyuki; Oshima, Takeshi; Koike, Hiroyuki Tetrahedron Letters, 1990 ,  vol. 31,  # 5  p. 699 - 702

Full Text: HTML

Citation Number: 17

Abstract

Abstract Potent PAF agonists (R)-3a, b were synthesized and converted into PAF. Key steps include Mitsunobu reaction of a chiral secondary alcohol with 3-hydroxyisoxazole as the acidic component, and hydrogenolytic ring cleavage of the resulting 3-isoxazolyloxy group into the inverted alcohol.