Process Development of 5-Methoxy-1 H-indole-2-carboxylic Acid from Ethyl 2-Methylmalonate

Y Bessard

Index: Bessard, Yves Organic Process Research and Development, 1998 , vol. 2, # 4 p. 214 - 220

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Citation Number: 10

Abstract

Development is described of a new process for the preparation from malonates of 5-methoxy- 1 H-indole-2-carboxylic acid esters, useful intermediates in the synthesis of pharmaceutical compounds. The process uses readily available starting materials, produces little waste, can be operated safely on at least 1 molar scale, and gives high yields. The main areas of optimization included the azo coupling of a diazonium salt with malonate derivatives, the ...