Synlett
Synthesis of oxazinyl analogues of fosmidomycin using RCM methodology
S Van der Jeught, CV Stevens, N Dieltiens
Index: Van Der Jeught, Sarah; Stevens, Christian V.; Dieltiens, Nicolai Synlett, 2007 , # 20 p. 3183 - 3187
Full Text: HTML
Citation Number: 7
Abstract
Abstract Fosmidomycin is a promising antimalarial compound with a novel mode of action, the inhibition of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a key enzyme in the biosynthesis of isoprenoids through the nonmevalonate pathway. This paper describes the synthesis of a series of analogues in which the hydroxamate moiety is incorporated in a ring structure, leaving the complexation with the enzyme up to the oxygen lone pairs instead of ...