3-Cyano-4, 6-dimethyl-5-R-pyridine-2-sulfonyl chlorides and N-substituted sulfonylamides based on them

IG Dmitrieva, LV Dyadyuchenko, VD Strelkov…

Index: Dmitrieva; Dyadyuchenko; Strelkov; Kaigorodova Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 9 p. 1047 - 1052

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Abstract

3-Cyanopyridine-2-sulfonyl chlorides were synthesized by the oxidative chlorination of the respective 3-cyanopyridine-2 (1H)-2-thiones. It was established that 3-cyano-4, 6- dimethylpyridine-2-sulfonyl chloride eliminates a SO 2 molecule at the isolation stage. N- Substituted sulfonylamides based on the latter were obtained by the reaction of the crude sulfonyl chloride with amines in an aqueous medium.