Microbial enantioselective removal of the N-benzyloxycarbonyl amino protecting group
M Maurs, F Acher, R Azerad
Index: Maurs, Michele; Acher, Francine; Azerad, Robert Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 22 - 26
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Abstract
In order to deprotect N-carbobenzoxy-l-aminoacids (Cbz-AA) and related compounds, a series of microorganisms was selected from soil by enrichment cultures with Cbz-l-Glu as sole nitrogen source. A lyophilized whole-cell preparation of two Arthrobacter sp. strains grown on Cbz-Glu or Cbz-Gly exhibited a high cleavage activity. The conditions of hydrolysis have been optimized and a quantitative enantioselective deprotection of several Cbz-dl- ...
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