The synthesis of substituted 2H-1, 2-benzothiazines 1, 1-dioxides

J Svoboda, J Paleček, V Dědek

Index: Svoboda, Jiri; Palecek, Jaroslav; Dedek, Vaclav Collection of Czechoslovak Chemical Communications, 1986 ,  vol. 51,  # 5  p. 1133 - 1139

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Citation Number: 6

Abstract

Abstract The base-catalyzed rearrangement of the esters of 2H-1, 2-benzothiazolin-3-one-2- acetate 1, 1-dioxide (IIa-IIc) afforded substituted 2H-1, 2-benzothiazine-3-carboxylate 1, 1- dioxides IIIa-IIIc. After N-alkylation and aminolysis the antiinflammatory drugs piroxicam and isoxicam were obtained.