New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties

S Eswaran, AV Adhikari, IH Chowdhury, NK Pal…

Index: Eswaran, Sumesh; Adhikari, Airody Vasudeva; Chowdhury, Imran H.; Pal, Nishith K.; Thomas European Journal of Medicinal Chemistry, 2010 , vol. 45, # 8 p. 3374 - 3383

Full Text: HTML

Citation Number: 83

Abstract

Four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl aniline through multi-step reactions. In the reaction sequence, substituted aniline was cyclized to 4-hydroxy quinoline 1, which was then transformed to 4-chloro-2, 8-bis (trifluoromethyl) quinoline 2. The key scaffold 4-hydrazinyl-2, 8-bis (trifluoromethyl) quinoline 3, obtained from the compound 2, was successfully converted to target quinoline ...