Carbostyril derivatives having potent. beta.-adrenergic agonist properties

J Milecki, SP Baker, KM Standifer, T Ishizu…

Index: Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al. Journal of Medicinal Chemistry, 1987 ,  vol. 30,  # 9  p. 1563 - 1566

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Citation Number: 36

Abstract

Results Chemistry. The method of synthesis of the carbostyril derivatives (Scheme I) was based on Goodman's approach to the synthesis of catecholamine derivatives. 11J6 Commercial 8-hydroxyquinoline was converted by aqueous formaldehyde-hydrogen chloride to the hydrochloride of 5-(chloromethyl)-8-hydroxyquinoline, which, by treatment with aqueous ammonia, yielded B-hydroxy-5-(hydroxymethy1) quinoline (1). Both of these ...