Synthesis and biological activity of fluorine-modified platelet activating factors.

…, S KOBAYASHI, I KUDO, K INOUE, S NOJIMA…

Index: Fujita; Kobayashi; Kudo; Inoue; Nojima; Ohno; Odagiri; Taguchi Chemical and Pharmaceutical Bulletin, 1987 ,  vol. 35,  # 2  p. 647 - 653

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Citation Number: 3

Abstract

Fluorine-modified acetyl glyceryl ether phosphorylcholines (platelet activating factors; PAFs) were efficiently synthesized in an enantioselective manner by the coupling of a D-threitol. derivative with fluorinated long-chain alkoxy methanesulfonates. The introduction of a trifluoromethyl group at the terminal of the alkyl ether chain decreased the hypotensive activity and platelet activation considerably. As the number of fluorine atoms in the alkyl ...