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Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-{[4-(substituted 2-quinoxalinyloxy) phenyl] acetyl} glutamates …

S Piras, M Loriga, G Paglietti

Index: Piras, Sandra; Loriga, Mario; Paglietti, Giuseppe Farmaco, 2004 , vol. 59, # 3 p. 185 - 194

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Citation Number: 37

Abstract

Fourteen out of 21 quinoxaline derivatives described in the present paper were selected at NCI for evaluation of their in vitro anticancer activity. Preliminary screening showed that some derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10–5 and 10–4 M concentrations. Interesting selectivities were also recorded between 10–8 and 10–6 M for the compounds 9 and 13.