Cytochalasan synthesis: total synthesis of cytochalasin H

EJ Thomas, JWF Whitehead

Index: Thomas, Eric J.; Whitehead, John W. F. Journal of the Chemical Society, Chemical Communications, 1986 ,  # 9  p. 727 - 728

Full Text: HTML

Citation Number: 4

Abstract

The final stages of a total synthesis of cytochalasin H are described. ... Synthesis of the cytochalasans,l an important group of biologically active, fungal metabolites, is an area of consider- able interest at the present time.2 In the preceding communi- cation we described the total synthesis of the [ ll]cytochalasan (1) using an intramolecular Diels-Alder reaction to close the 11-membered ring.2 We now report the conversion of this adduct into cytochalasin H ...