Journal of fluorine chemistry

The synthesis of a fluorinated analogue of 5-aminolaevulinic acid, a potential inhibitor of porphyrin biosynthesis

FJ Leeper, M Rock

Index: Leeper, Finian J.; Rock, Martin Journal of Fluorine Chemistry, 1991 ,  vol. 51,  # 3  p. 381 - 396

Full Text: HTML

Citation Number: 13

Abstract

Abstract 5-Amino-2-fluorolaevulinic acid 3 has been synthesized in high yield by modification of a new route to 5-aminolaevulinic acid (ALA), involving γ-lactone intermediates. Initial studies suggest that 3 is an inhibitor of ALA dehydratase, an early enzyme of tetrapyrrole biosynthesis.