A rapid and efficient synthesis of β-casomorphin employing Boc-amino acids and 9-fluorenylmethyl chloroformate as a coupling agent

VV Babu, SJ Tantry

Index: Babu, V.V. Suresh; Tantry Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 ,  vol. 43,  # 12  p. 2708 - 2712

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Abstract

Abstract: The synthesis of β-casomorphin H-Tyr-Pro-Phe-Pro-Gly-OH employing Boc group for N α-protection and 9-fluorenylmethyl chloroformate (Fmoc-CI) for the formation of peptide bond is described. The protocol employing Fmoc-Cl as coupling reagent is found to be simple, efficient and rapid. All the intermediate peptides as well as the final protected peptide Boc-Tyr (t Bu)-Pro-Phe-Pro-Gly-OMe have been isolated and fully characterized. ...