Synthetic communications

An improved preparation of 4-hydroxymethyl-L-phenylalanine

E Morera, G Ortar, A Varani

Index: Morera, Enrico; Ortar, Giorgio; Varani, Aurelio Synthetic Communications, 1998 ,  vol. 28,  # 22  p. 4279 - 4285

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Citation Number: 20

Abstract

Abstract Palladium-catalyzed hydroformylation of methyl esters of N-Boc-L-tyrosine triflate (1a) and N-Boc-4-iodo-L-phenylalanine (1b) followed by reduction with sodium borohydride and standard deprotection procedures affords the title compound in 77 and 83% overall yield, respectively.