Nontricyclic antidepressant agents derived from cis-and trans-1-amino-4-aryltetralins

WM Welch, AR Kraska, R Sarges…

Index: Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth Journal of Medicinal Chemistry, 1984 ,  vol. 27,  # 11  p. 1508 - 1515

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Citation Number: 178

Abstract

The need for drugs that lack the obtrusive and limiting side effects of the tricyclic antidepressants has prompted the search for agents with greatly enhanced selectivity for specific mechanisms believed to be essential for antidepressant efficacy. The potential role of derangements of 5-HT pathways in the etiology of depression has long been suspected and has given impetus to the development of newer compounds that accentuate inhibition ...