Molecules

Synthesis and contractile activity of substituted 1, 2, 3, 4-Tetrahydroisoquinolines

…, S Nikolova, D Aladjov, I Stefanova, P Zagorchev

Index: Ivanov, Iliyan; Nikolova, Stoyanka; Aladjov, Dimo; Stefanova, Iliyana; Zagorchev, Plamen Molecules, 2011 ,  vol. 16,  # 8  p. 7019 - 7042

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Citation Number: 9

Abstract

Abstract A series of different 1-monosubstituted and 1, 1-disubstituted 1, 2, 3, 4-tetrahydro- isoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction of ketoamides with organomagnesium compounds, followed by cyclization in the presence of catalytic amounts of p-toluenesulfonic acid (PTSA). A number of substituents at the C-1 in ...