Enantioselective Formation of tert??Alkylamines by Desymmetrization of 2??Substituted Serinols

MS Hong, TW Kim, B Jung…

Index: Hong, Mi Sook; Kim, Tae Woo; Jung, Byunghyuck; Kang, Sung Ho Chemistry - A European Journal, 2008 , vol. 14, # 11 p. 3290 - 3296

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Citation Number: 21

Abstract

Abstract Novel enantioselective desymmetrization of 2-substituted 2-amino-1, 3- propanediols has been established to generate asymmetric quaternary carbon centers comprising an amino group. Enantioselective as well as chemical conversion proved to be greatly dependent on the protecting group of the amino group in the substrate, desymmetrizing reagent, base, solvent, and naturally, catalyst. The highly effective ...