Potential Protein Kinase C Inhibitors. 8, 9, 10, 11α:??Tetrahydro??7αH??7, 11??methano??12, 12??dimethylcycloocta [de] naphthyl??9??amines

…, RE BOWMAN, H SMITH, PJ NICHOLLS…

Index: Wilson, Martin P.; Bowman, Ralph E.; Smith, H. John; Nicholls, Paul J.; Hewlins, Michael J. E. Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 2 p. 160 - 171

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Abstract

Welsh School of Pharmacy and *Chemistry Department, UWCC Cathays Park, CardiflCFI 3XF, UK ... Abstract The synthesis of the 9a- and 9P-epimers of 8, 9, 10, 11a-tetrahydro-7aH-7, Il-methano-12, 12- dimethylcycloocta [de] naphthyl-9-amine is described. ... Protein kinase C (PKC) is of pivotal importance in certain signal transduction pathways (Borner & Fabbro 1992). Inhibitors of this enzyme may be of use in a wide variety of ...