Studies on enaminonitriles: A new synthesis of 1, 3??substituted pyrazole??4??carbonitrile

…, IA Abdelhamid, MH Elnagdi, HM Gaber

Index: Ghozlan, Said Ahmed Soliman; Abdelhamid, Ismail Abdelshafy; Gaber, Hatem Moustafa; Elnagdi, Mohamed Hilmy Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 6 p. 1185 - 1189

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Citation Number: 32

Abstract

Abstract 3-Diethylaminoacrylonitrile (1) reacts with hydrazonyl halides (2a-d) to yield 1, 3- disubstituted pyrazole-4-carbonitriles 5a-d. The acetyl 1-p-chlorophenylpyrazole-4- carbonitrile (5a) condensed with hydrazine hydrate to yield the bishydrazone 10 and with dimethylformamide dimethylacetal to yield 1-aryl-3-(3-dimethylamino) acryloyl pyrazole-4- carbonitrile (11). This enamine reacts with hydrazine hydrate to yield the ...