Acetylenic Acids Inhibiting Azole-Resistant Candida a lbicans from Pentagonia g igantifolia

XC Li, MR Jacob, HN ElSohly, DG Nagle…

Index: Li, Xing-Cong; Jacob, Melissa R.; ElSohly, Hala N.; Nagle, Dale G.; Smillie, Troy J.; Walker, Larry A.; Clark, Alice M. Journal of Natural Products, 2003 , vol. 66, # 8 p. 1132 - 1135

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Citation Number: 27

Abstract

Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and-resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 ...