Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo [2.2. 1] heptane: a potent imidazoline1 receptor specific agent

…, AB Kharlamb, CA Manlapaz, EU Padillo…

Index: Munk; Lai; Burke; Arasasingham; Kharlamb; Manlapaz; Padillo; Wijono; Hasson; Wheeler; Garst Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1193 - 1195

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Citation Number: 42

Abstract

Bousquet et al., Coupry et al., and Ernsberger et al. in the 1980s. 1 Recently, agmatine (1, Figure 1) has been proposed to be the endogenous ligand for the I receptors. 2 There is some question whether agmatine is the sole endogenous agent. 3 These receptors do not interact with catecholamines including norepinephrine (2), the natural ligand for adrenoceptors. The imidazoline family of receptors does, however, recognize many ...