Synthesis and In Vitro Cytotoxic Evaluation of 7-Chloro-4-anilino-quinoline Amide Derivatives

BT Hieu, VT Thuy, HX Tien…

Index: Trung Hieu, Bui; Thuy, Vu Thu; Tien, Hoang Xuan; Vu, Tran Khac Asian Journal of Chemistry, 2013 , vol. 25, # 8 p. 4453 - 4456

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Abstract

Abstract A series of new amide derivatives of 4-anilino-quinoline have been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1) and human breast cancer (MCF-7). Compound 5g was found to be most potent cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 2.09 and 4.63 μg/mL, respectively. Compound 5e exhibited significant ...