The effects of substituents introduced into 9-aminoacridine on frameshift mutagenicity and DNA binding affinity

H Tomosaka, S Omata, E Hasegawa…

Index: Tomosaka, Hideyuki; Omata, Saburo; Hasegawa, Eietsu; Anzai, Kentaro Bioscience, Biotechnology and Biochemistry, 1997 , vol. 61, # 7 p. 1121 - 1125

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Citation Number: 18

Abstract

Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.