The total synthesis of 12-HETE (12-hydroxyeicosatetraenoic acid) and 12, 20-diHETE

Y Leblanc, BJ Fitzsimmons, J Adams…

Index: Leblanc, Yves; Fitzsimmons, Brian J.; Adams, Julian; Perez, Francoise; Rokach, Joshua Journal of Organic Chemistry, 1986 ,  vol. 51,  # 6  p. 789 - 793

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Citation Number: 86

Abstract

2: R= CH20H 12, ZO-dlHETE arachidonic acid by a 12-lipoxygenase enzyme, which is found in platelets' and skin, keratinocytes. 2 The 12-HETE is of particular interest since it has been detected in high concentrations in psoriatic lesions3 and has been shown to possess both chemotactic and chemokinetic properties. The 12 (S)-HETE is also the major lipoxygenase-derived arachidonic acid metabolite produced by the platelet and has been ...