Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs

ND Chaurasiya, S Ganesan, NPD Nanayakkara…

Index: Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L. Bioorganic and Medicinal Chemistry Letters, 2012 ,  vol. 22,  # 4  p. 1701 - 1704

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Citation Number: 6

Abstract

8-Aminoquinolines (8-AQs) are important class of anti-infective therapeutics. 5-Phenoxy 8- aminoquinoline analogs have shown improved metabolic stability compared to primaquine. In view or predictive role of monoamine oxidases (MAO) in metabolism of 8-aminoquinolines the 5-phenoxy analogs were evaluated in vitro for the inhibition of recombinant human MAO- A and MAO-B. The analogs were several folds more potent inhibitors of MAO-A and MAO- ...