A facile one-pot synthetic method for 1, 2, 4-triazoles and 1, 3-disubstitued thioureas
OM Singh, SJ Singh
Index: Singh, Okram Mukherjee; Singh, Sarangthem Joychandra Journal of Chemical Research, 2006 , # 8 p. 483 - 485
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Abstract
The reaction of arylisothiocyanates with triethylamine and acylhydrazides in the presence of mercuric acetate has been studied. The reaction proceeds through the formation of thiourea, followed by a sequential addition-dehydration with acylhydrazides. The initial detection of thiourea, which mediates the formation of disubstituted 1, 2, 4-triazoles, is explained by a plausible mechanism.
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[Guin, Srimanta; Rout, Saroj Kumar; Gogoi, Anupal; Nandi, Shyamapada; Ghara, Krishna Kanta; Patel, Bhisma K. Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2757 - 2770]