Synthesis of new 2, 5-diamino-1, 3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas
AG Balya, AN Chernega, SA But, AN Vasilenko…
Index: Balya; Chernega; But; Vasilenko; Brovarets; Drach Russian Journal of General Chemistry, 2008 , vol. 78, # 7 p. 1427 - 1435
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Abstract
Abstract N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N, N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2, 5-diamino-1, 3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2- thiohydantoins on heating with hydrochloric acid in ethanol.
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