(-)-Spiro [1-azabicyclo [2.2. 2] octane-3, 5'-oxazolidin-2'-one], a Conformationally Restricted Analogue of Acetylcholine, Is a Highly Selective Full Agonist at the α7 …

…, P Verhoest, A Sampognaro, E Phillips…

Index: Mullen; Napier; Balestra; Decory; Hale; Macor; Mack; Loch III; Wu; Kover; Verhoest; Sampognaro; Phillips; Zhu; Murray; Griffith; Blosser; Gurley; Machulskis; Zongrone; Rosen; Gordon Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4045 - 4050

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Citation Number: 143

Abstract

Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel receptor superfamily and may play important roles in modulating neurotransmission, cognition, sensory gating, and anxiety. Because of its distribution and abundance in the CNS, the α7 nicotinic receptor is a strong candidate to be involved in some of these functions. In this paper we describe the synthesis and in vitro profile of AR-R17779,(-)- ...