Il Farmaco

Synthesis and anticonvulsant activity of some (2/4-substituted) benzaldehyde (2-oxobenzothiazolin-3-yl) acetohydrazones

B Çakir, E Yildirim, T Ercanli, K Erol, MF Sahin

Index: Cakir, Bilge; Yildirim, Engin; Ercanli, Taner; Erol, Kevser; Sahin, M. Fethi Farmaco, 1999 , vol. 54, # 11-12 p. 842 - 845

Full Text: HTML

Citation Number: 22

Abstract

Fifteen new (2/4-substituted) benzaldehyde (2-oxobenzothiazolin-3-yl) acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others.