Antioxidation and tyrosinase inhibition of polyphenolic curcumin analogs

ZY Du, YF Jiang, ZK Tang, RQ Mo, GH Xue…

Index: Du, Zhi-Yun; Jiang, Yong-Fu; Tang, Zhi-Kai; Mo, Rong-Qing; Xue, Gui-Hua; Lu, Yu-Jing; Zheng, Xi; Dong, Chang-Zhi; Zhang, Kun Bioscience, Biotechnology and Biochemistry, 2011 , vol. 75, # 12 p. 2351 - 2358

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Citation Number: 15

Abstract

A series of polyphenolic curcumin analogs were synthesized and their inhibitory effects on mushroom tyrosinase and the inhibition of 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) free radical formation were evaluated. The results indictated that the analogs possessing m- diphenols and o-diphenols exhibited more potent inhibitory activity on tyrosinase than reference compound rojic acid, and that the analogs with o-diphenols exhibited more ...