Inhibition of cyclic adenosine-3', 5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogs

MC Marivet, JJ Bourguignon, C Lugnier…

Index: Marivet; Bourguignon; Lugnier; Mann; Stoclet; Wermuth Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1450 - 1457

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Citation Number: 80

Abstract

Compounds were tested on the three different forms of PDE isolated from bovine aorta. 6 The first form hydrolyzed preferentially cGMP and was activated 6-15-fold by calmodulin (CaM); it was named CaM-PDE. The second form hydrolyzed cGMP with a high degree of selectivity and was insensitive to CaM and cGMP; it was called cGMP-PDE. The third peak hydrolyzed preferentially cAMP and was not stimulated by CaM; it was named CAMP-PDE ...