Synthesis of Skeletally Diverse Alkaloid??Like Small Molecules

…, C Einzinger, B McKeever??Abbas…

Index: Murrison, Sarah; Maurya, Sushil K.; Einzinger, Christian; McKeever-Abbas, Ben; Warriner, Stuart; Nelson, Adam European Journal of Organic Chemistry, 2011 , # 12 p. 2354 - 2359

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Citation Number: 9

Abstract

Abstract A synthetic approach to skeletally diverse alkaloid-like compounds, involving two consecutive three-component reactions, was developed. First, reaction between a range of secondary amines, carbonyl compounds and triazines yielded cyclic imines. Crucially, the identity of the substituents in the amine and carbonyl compound components determined– through a “folding” pathway–the alkaloid-like scaffold that was prepared. The cyclic imine ...